When using Spatial Analyst I regularly have issues with NoData values cropping up in the data. Various tools appear to introduce NoData values regularly. These values then cause issues with other tools and have to be eliminated with reclassification, usually resulting in other problems.
How should NoData values be dealt with? Is there a simple way to replace NoData values with zero? Can NoData be avoided altogether?

-9999), and1.#QNANNoData. In ArcGIS the former is transparent, while1.#QNANNoData is opaque black. – Mike Toews Apr 11 '11 at 19:41