New answers tagged personal-geodatabase
I think even ESRI would recommend staying away from the .mdb-based personal geodatabase and instead use the File Geodatabase, and in that case you can use QGIS for that: File Geodatabase (*.gdb) support in QGIS? How to access file geodatabase in Qgis?
QGIS would most likely be relying on the GDAL driver for Personal Geodatabases support which currently only supports read capability (so no creation or writing to one). You can see some info on the PGeo driver at http://gdal.org/drv_pgeo.html
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