I am using Manifold 8, with the IronPython 2.6 distribution.
I've gotten Manifold to at least be able to run IronPython scripts (courtesy of http://www.georeference.org/Forum/t100925.11) by deleting the Scripts > Reference to IronMath.dll and changing the IronPython.dll reference to full file path.
However, despite being able to load up IronPython itself and import, say, urllib2 just fine, I can't do the same in Manifold. Instead I get:
Exception has been thrown by the target of an invocation. No module named urllib2 [sic]
At the same time, I can do import math and then junk like math.sqrt(), and if I don't import math then math.sqrt() throws an error. This and the fact that Manifold knows the error suggests that the software should be able to import modules, but I don't know why it can't get urllib2 or cmd or whatever.
I've tried adding a reference to IronPython.Modules.dll in references, as well as a bunch of other DLLs that are in the IronPython 2.6 folder.
Given how little stuff there is about Manifold on here I'm not hopeful about finding a positive answer, but who knows. Maybe someone out there will have an idea or relevant experience that might assist despite not knowing Manifold GIS specifically.