I could use the statistical tests like t-test and ANOVA, however I am afraid those test will easily show significant differences if I use the slope values of all cells from each area.

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    What GIS software are you using? Please edit your question/tags to include that information. – MaryBeth Jan 5 '16 at 20:37
  • What about the basic summary stats like min, max, mean, variance, std etc. Are you starting with elevation values, or actual slope values? – bcollins Jan 5 '16 at 20:38
  • I am using slope values – Neto Garcia Jan 5 '16 at 21:11
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    Please tell us why you are comparing the slopes. What do you hope to achieve with this comparison? What is it intended to represent? – whuber Jan 6 '16 at 1:27
  • I would like to be able to say if one are is different from the other, on slope wise! – Neto Garcia Jan 6 '16 at 1:42