I need disable or hide the Customize option. I have listen about a mxd file configuration, but isn't clear to me.
Is there any way?
I'm using ArcGIS 10.4
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Click on Customize > Customize Mode
When the window opens, just drag the Customize menu option from your toolbar.
Now the Customize option will be gone from your menubar.
To get it back you will need to open Customize Mode again, this time from a right-click on a toolbar > Customize (since you've removed the Customize menu). On the toolbars tab scroll down and find Main Menu and click the Reset button.
This will reset your Main Menu toolbar to restore any items you have removed from the default.
You can lock your modifications to these toolbars from the Customize window by adding a password. Click on the Options tab and select Lock Customization
Enter and confirm a password
Now when you try to open the Customize window again (via Customize > Customize mode or via right-click > Customize) it will prompt for a password.
If the correct password is not entered, no customization can be made to the toolbars or menus.
Be aware you can restrict these customization and lock to the document or to ArcMap on the machine by checking or unchecking the "Save all customizations to the document" option on the Options tab.