I came across this issue regarding labels overlapping annotations in ArcMap 10.6 (picture left) where they don't overlap in 10.5 (picture right)... What am I missing? I simply opened the mxd in the newer version so the settings are all the same (I would have guessed, but obviously 10.6 ignores some of them):
I use the Maplex Label Engine and already tried to add another polygon feature class serving as a mask for my annotations, giving it a feature weight of 1000 (both interior and boundary) which should block all labels from being displayed in that area. But that is simply being ignored!