At work with the Ontario Geological Survey where we use ArcMap (10.6), I can select a number of annotation text and change the properties of the selected text.
To date, at home using QGIS 3.18 (Linux), I am unable to figure out if this is even possible, let alone how to do it.
Sorry for not being clear enough, here's some additional info.
Easting and Northing labels at the end of each line (nodes) whereby the Easting labels at the top of the map are centered on the node 1mm above the neatline, the Easting labels are centered 1mm below the neatline, the Northing labels on the right side of the map are 1mm right of the neatline and the Northing labels on the left side of the map are 1mm left of the neatline.
In ArcMap, I can select the left Northings and apply right alignment, select the right Northings and apply left alignment, etc. It appears that alignment works differently in QGIS but I've figured out that Placement>Offset from point using the top/bottom/right/left quadrants with a 1mm offset does exactly what I want it to do but I don't know how to select the labels on the left and apply their specific Placement settings that are different from each of the groups of labels.