If you use an Iterator within model builder, you can grab a folder containing multiple rasters and it will separate them within and apply the next process to all of them congruently
Set raster format as GRID
Under data management tools> Calculate Statistics
If this isn't what you are looking for, you can always create a mosaic dataset with the desired raster GRIDs and select your preferences as it applies to composite bands.
From here you can apply raster function chains to process different analyses and calculate statistics to display values correctly
To do this you need to first create a file geodatabase, then create a mosaic dataset, from here you right click and add rasters
make sure format is correct and check boxes for Overview creation and calculate statistics
Hope this is a start, let me know if you need anymore assistance with this process