Does the MXD Defrag program still exist in ArcGIS 10?
The MXD Defrag program is installed (on my Win 7 machine) here:
C:\Program Files (x86)\ArcGIS\Desktop10.0\Tools\DocDefragmenter.exe
Just a couple of things I've changed so far - In the Advanced setting utility:
I set the temporary metafile size limit to 10MB. Not because of anything I've run into in Arc10 yet, but I did have problems in 9.3 and earlier, and this setting seemed to help.
I set the Output raster buffer size to 32MB in order to improve image export speed.
Using the Document Defragmenter utility might be helpful:
The ArcGIS Document Defragmenter utility defragments the storage inside an .mxd file to potentially reduce the file size. This utility is useful if your .mxd files are large in size. The utility can also defragment .sxd, .3dd, and, .mxt files. The utility is located in the Utilities folder of the ArcGIS Desktop installation directory. By default, that location is :\Program Files\ArcGIS\Desktop10.0\Tools.