I wrote the following script, which runs fine from the QGIS python console (it loads two shapefiles, intersects them, and then finds the areas of the new regions): import qgis.utils import qgis.core from qgis.analysis import * from PyQt4.QtCore import QVariant import os print(os.getcwd()) layer1 = iface.addVectorLayer("/Users/casta2k/ShapefilePractice/precincts/USA_precincts.shp", "precincts", "ogr") layer2 = iface.addVectorLayer("/Users/casta2k/ShapefilePractice/data_EPSG_4326/Bnd_2015_q1_region.shp", "zipcodes", "ogr") overlayAnalyzer = QgsOverlayAnalyzer() overlayAnalyzer.intersection(layer1, layer2, "/Users/casta2k/ShapefilePractice/intersect/intersectOutput.shp") layer3 = iface.addVectorLayer("/Users/casta2k/ShapefilePractice/intersect/intersectOutput.shp", "intersect", "ogr") layer = iface.activeLayer() provider = layer.dataProvider() areas = [ feat.geometry().area() for feat in layer.getFeatures() ] field = QgsField("area", QVariant.Double) provider.addAttributes([field]) layer.updateFields() idx = layer.fieldNameIndex('area') for area in areas: new_values = {idx : float(area)} provider.changeAttributeValues({areas.index(area):new_values}) I'd like to be able to run the code directly from a python script, without having to open the GUI. I've tried searching the internet, but I've found nothing helpful. Do I have to start by running QgsApplication.initQgis()? I thought I had to, but I get a segmentation fault. Also, I tried changing iface.addVectorLayer() to QgsVectorLayer(), which seems to work fine in the Python console, but it seems like the files aren't loaded when I run the python script directly. As you can see, I'm very lost here (the documentation that is available is very poor), so I would appreciate any help. Thanks!