As long as all your data sits within the same file geodatabase (so you will need to import your Excel file into it as a table) you can use the [Make Query Layer][1] tool to join on multiple fields. It's a very powerful tool but takes a little effort to play with the parameter settings and actually take the time to read the help file to understand what is what.


  [1]: https://pro.arcgis.com/en/pro-app/2.8/tool-reference/data-management/make-query-layer.htm