You're pretty much there with your code. You just need to set the SR on the map ras= "my_layer.tif" sr=arcpy.Describe(ras).spatialReference p = arcpy.mp.ArcGISProject(r"\\ptemplate\project.aprx) m = p.listMaps()[0] m.spatialReference = sr p.saveACopy(r"\\my_projects\project_out.aprx)