I am having trouble publishing a map file using ArcGIS publisher. This mxd is intended for use by ArcReader but I keep getting a "file access error message asking me to check that the file permissions are correct and that it is not already open by another application".
I have been granted permission to publish on a shared drive and do not believe this mxd is being used by another application. 
Does anybody have an idea what else I can try to make it work?

Thank you so much.