I had the same issue and I would like to share my solution to the problem : 1) First make sure that you have the necessary hdf4 drivers installed : ****apt-get install libhdf4-dev** **apt-get install proj-bin** **apt-get install libproj-dev** **apt-get install libgdal-dev** **apt-get install gdal-bin** (Thanks to user @mdsumner for this) 2) Then there seems to be a issue with the pyModis package itself as explained by Luca here : https://github.com/lucadelu/pyModis/issues/29#issuecomment-104800294 So I removed pymodis and installed the new version directly form the Github site, run the following command **sudo pip git+https://github.com/lucadelu/pyModis.git** and then to be sure run an upgrade and then TADA !!! The HDF4 problem should be gone when you import pymodis. Hope it helps ~cheers