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To speed up the process you could use gdallocationinfo with input/output redirection. Export all your lat/lon values to input.csv and read the corresponding cell values from output.csv: os.system(r'gdallocationinfo -valonly -wgs84 "%s" <%s >%s' % ('dhm.tif','input.csv','output.csv')) with open('output.csv','r') as f: result = f.read()

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