Is it possible to generate Vector Tiles using the 2.2.0 Mapnik release? If so, please give a sample configuration or point to an example.
You could find a good point to start here.
It's the other way around. Mapnik is software to render images from data. Vector tiles are data. You can use Mapnik to render images from Vector Tiles. You cannot use Mapnik to output Vector Tiles.
No, Mapnik 2.2.0 will not generate vector tiles out of the box. To enable this functionality, it must be compiled with C++ headers available here.